Rapid tablet swelling and disintegration during exposure to brightness-mode ultrasound

Abstract Controlled tablet disintegration is useful for chemical consistency checks. This study monitored the swelling of 54 analgesia tablets from two different batches, during 13–6-MHz brightness-mode sonication and simultaneous video recording. The were placed on an acoustic reflector inside a container sonicated top. Sonication shortened displacement half-life by 17%–27%. During swelling, their speed sound increased linearly, confirming linearity this process. Diagnostic ultrasound significantly decreased times, supporting ultrasound–microbubble interaction hypothesis.